Literature Review : Medication Compliance in Tuberculosis Patients

Authors

  • Umi Kalsum Universitas Muhammadiyah Palu
  • Tri Mayang Amita Universitas Muhammadiyah Palu, Indonesia
  • Lisdiawati Lisdiawati Universitas Muhammadiyah Palu, Indonesia
  • Sudirman Sudirman Universitas Muhammadiyah Palu, Indonesia
  • Ahmad Yani Universitas Muhammadiyah Palu, Indonesia

DOI:

https://doi.org/10.58344/jws.v4i4.1403

Keywords:

Tuberculosis, Medication Adherence, Treatment Compliance, Drug-Resistant TB, Patient Education, Global Health

Abstract

Tuberculosis (TB) remains one of the leading global health challenges, with a high incidence of infection, widespread drug resistance, and significant morbidity, especially in low- and middle-income countries. Despite advancements in diagnostic tools, treatment regimens, and global policy support, adherence to TB medication remains a critical issue. This study aims to examine the factors influencing medication adherence among TB patients and assess the effectiveness of interventions designed to improve compliance. The research utilizes a literature review methodology, analyzing secondary data obtained from 15 journals and articles published between 2019 and 2024. The findings indicate that knowledge, family support, and healthcare access are key in improving TB treatment adherence. Integrating community-based interventions and educational programs has positively enhanced patient compliance. Additionally, addressing socio-economic factors such as poverty and inadequate healthcare access is essential in reducing TB incidence and preventing drug-resistant strains. The study emphasizes the importance of continuous monitoring, patient education, and support to ensure effective TB control and treatment. The results contribute to the development of targeted strategies for improving TB treatment adherence, particularly in regions with high TB burden.

References

Global tuberculosis report 2024. (2024).

Kemenkes RI. (2020). Tuberkulosis. Pusat Data dan Informasi. In (Kementerian Kesehatan Republik Indonesia.

Kementerian Kesehatan Republik Indonesia, “Profil Kesehatan Indonesia 2021,” Profil Kesehat. Indones. 2021, 2022.

Yunitasari, R., Akbar, I. B., & Nurmeliani, R. (2023, January). Korelasi Kinerja Pengawas Menelan Obat dengan Kepatuhan Minum Obat Pasien Tuberkulosis Paru. In Bandung Conference Series: Medical Science (Vol. 3, No. 1, pp. 19-24).

Chairani, C., Utami, P. R., Indrayati, S., Almurdi, A., & Rahmayana, R. (2023). Perbedaan Hasil Pemeriksaan Mikroskopis BTA Pada Pasien TB Paru Sebelum dan Sesudah Pengobatan Fixed-Dose Combination (FDC) Fase Intensif. Jurnal Kesehatan Perintis, 10(1), 68-73.

Suryana, I., & Nurhayati, N. (2021). Hubungan Antara Peran Pengawas Menelan Obat (PMO) Terhadap Kepatuhan Minum Obat Penderita TB Paru. Indonesian Journal of Nursing Sciences and Practice, 4(2), 93-98.

Kusmiyani, O. T., Hermanto, H., & Rosela, K. (2024). Analisis Faktor yang Berhubungan dengan Kepatuhan Minum Obat Anti Tuberkulosis pada Pasien TB Paru di Puskesmas Samuda dan Bapinang Kotawaringin Timur: Analysis of Factors Related to Compliance with Taking Anti-Tuberculosis Drugs in Pulmonary TB Patients at Samuda and Bapinang Health Centers East Kotawaringin. Jurnal Surya Medika (JSM), 10(1), 139-151.

Pratiwi, D. D., & Syafina, I. (2025). Tingkat Kepatuhan Minum Obat Anti Tuberkulosis (OAT) Berhubungan Terhadap Kesembuhan Pasien Tuberkulosis Paru Di Rumah Sakit Umum Daerah Rokan Hulu. JURNAL PANDU HUSADA, 6(3), 11-20.

World Health Organization. (2023). Global Tuberculosis Report 2023. Geneva: WHO. Retrieved from https://www.who.int

Mujahidah, Z., Silalahi, M. K., Prestisia, R. P., & Djubaidah, S. (2023). Hubungan Tingkat Pengetahuan dan Sikap Pasien Tuberkulosis Dengan Perilaku Pencegahan Penularan Penyakit Tuberkulosis Paru di Poli Paru. Jurnal Ilmiah Kesehatan, 15(1), 130–136. https://doi.org/10.37012/jik.v15i1.1103.

Ezzah El, D. (2024). ASUHAN KEPERAWATAN PASIEN YANG MENGALAMI TUBERKUOSIS PARU DENGAN BERSIHAN JALAN NAPAS TIDAK EFEKTIF DI RUMAH SAKIT PASAR REBO JAKARTA TIMUR (Doctoral dissertation, Universitas Mohammad Husni Thamrin).

Zain.I.M, & Utami. W.S(2020). Sistem Informasi Geografis. Unesa University Press

Anzari, Y., & Wibowo, S. (2025). Sistem Informasi Geografis Pemetaan Penyebaran TBC di Provinsi Jambi Tahun 2022. Technologica, 4(1), 44-52.

Pralambang, S. D., & Setiawan, S. (2021). Faktor risiko kejadian tuberkulosis di Indonesia. Jurnal Biostatistik, Kependudukan, Dan Informatika Kesehatan, 2(1), 5.

Handayani, S., & Musfirah, A. (2024). Determinan Kejadian Tuberkulosis Paru pada Pasien Rawat Jalan di RSUD Daya Kota Makassar. Jurnal Ilmiah Kesehatan (JIKA) Vol, 6(1).

Fransiska M, Hartati E. Faktor Resiko Kejadian Tuberculosis. J Kesehat. 2019;10(3):252-260.

Putri, I. D. M., & ABADI, A. (2024). MODEL PENYEBARAN TUBERCULOSIS DENGAN PENGURANGAN WAKTU KONTAK DAN VAKSINASI. MATHunesa: Jurnal Ilmiah Matematika, 12(2), 311-321.

Nugroho, A. A., Azhar Aziz, M., Yasser, A., & Tanjung, A. (2023). Analisis dan Simulasi Parameter Model Susceptible Vaccinated Infected Recovered (SVIR) pada Penyebaran Tuberkulosis di Indonesia. JURNAL INTEGRASI SAINS DAN QUR’AN (JISQu), 2(1), 114-120

Tilahun, G. T., Belachew, M. T., & Gebreselassie, Z. (2020). Stochastic model of tuberculosis with vaccination of newborns. Advances in Difference Equations(1), 658.

Kelemu Mengistu, A., & Witbooi, P. J. (2019). Modeling the Effects of Vaccination and Treatment on Tuberculosis Transmission Dynamics. Journal of Applied Mathematics.

Egonmwan, A. O., & Okuonghae, D. (2019). Mathematical analysis of a tuberculosis model with imperfect vaccine. International Journal of Biomathematics, 12(7), 1-30.

Sari, Desty Gusti, Rosatya Imanuela, and Resultanti Resultanti, 2022 “Abses Iliopsoas Akibat Tuberkulosis: Sebuah Laporan Kasus.” Jurnal Penyakit Dalam Indonesia11(3):7.

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Published

2025-05-14

How to Cite

Kalsum, U., Amita, T. M. ., Lisdiawati, L., Sudirman, S., & Yani, A. (2025). Literature Review : Medication Compliance in Tuberculosis Patients. Journal of World Science, 4(4), 438–449. https://doi.org/10.58344/jws.v4i4.1403