Treatment of Obesity with Diethylpropion as an Appetite Suppressant
DOI:
https://doi.org/10.58344/jws.v5i2.1626Keywords:
Diethylpropion, obesity, weight lossAbstract
Obesity and the Use of Diethylpropion: A Review — Obesity is a medical condition characterized by excessive fat accumulation, elevated body weight, and increased waist circumference. It can manifest at any age and is influenced by various factors, including lifestyle, socioeconomic status, and behavioral patterns. Addressing obesity is critical due to its association with an increased risk of comorbidities. This review aims to evaluate the safety and efficacy of diethylpropion as a short-term pharmacotherapy for obesity. This article is based on a comprehensive literature review conducted across multiple databases, including PubMed, Scopus, Springer, Elsevier, NCBI, and Google Scholar, utilizing the search terms “diethylpropion” and “obesity.” The literature search included studies published between 2015 and 2025. Research indicates that diethylpropion has demonstrated significant reductions in both weight and waist circumference. It is considered safe for patients with a history of hypertension and is associated with minimal side effects. The medication’s effectiveness may be influenced by factors such as the timing of administration, genetic predisposition, and gender. In conclusion, diethylpropion represents a viable option for the short-term management of obesity in patients who have not achieved success through lifestyle modifications.
References
Awaliyyah, N. (2025). Hubungan Frekuensi Konsumsi Makanan Cepat Saji (Fast Food) Dengan Obesitas Pada Remaja Di Smp Negeri 11 Kota Jambi. Keperawatan.
Celletti, F., Farrar, J., & De Regil, L. (2025). World Health Organization guideline on the use and indications of glucagon-like peptide-1 therapies for the treatment of obesity in adults. Jama.
Cortés?Moreno, G. Y., Roa?Coria, J. E., Zúñiga?Romero, Á., Huerta?Cruz, J. C., Lara?Padilla, E., del Valle?Laisequilla, C. F., Rocha?González, H. I., & Reyes?García, J. G. (2018). Anorectic efficacy and safety of the diethylpropion?topiramate combination in rats. Drug Development Research, 79(5), 225–233.
da Silva, D. S., Dos Santos, M. C., Domingos, L. F., Cordeiro, J. P., Miranda, K., Siqueira Tavares, M. G., Santos, K. C. C., Lima-Leopoldo, A. P., & Soares Leopoldo, A. (2025). Improved physical performance in obesity-resistant rats compared to obesity-prone rats: Effects of different diets and metabolic analysis. Plos One, 20(7), e0327670.
Febriyanti, R. M., Irawan, A. A., Anggriani, N., Andriyana, Y., & Abdulah, R. (2025). Challenges in implementing Indonesia’s community-based chronic disease management program (Prolanis): A scoping review. AIMS Public Health, 12(3), 890.
Gerstner, C., Saín, J., Lavandera, J., González, M., & Bernal, C. (2021). Functional milk fat enriched in conjugated linoleic acid prevented liver lipid accumulation induced by a high-fat diet in male rats. Food & Function, 12(11), 5051–5065.
Gómez-Silva, M., Piñeyro-Garza, E., Vargas-Zapata, R., Gamino-Peña, M. E., León-García, A., de León, M. B., Llerena, A., & León-Cachón, R. B. R. (2019). Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial. Scientific Reports, 9(1), 17833.
Henning, R. J. (2021). Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity. American Journal of Cardiovascular Disease, 11(4), 504.
Hruby, A., & Hu, F. B. (2015). The epidemiology of obesity: a big picture. Pharmacoeconomics, 33(7), 673–689.
Kalyanasundar, B., Solorio, J., Perez, C. I., Hoyo-Vadillo, C., Simon, S. A., & Gutierrez, R. (2016). The efficacy of the appetite suppressant, diethylpropion, is dependent on both when it is given (day vs. night) and under conditions of high fat dietary restriction. Appetite, 100, 152–161.
Mahase, E. (2022). Obesity: No European country is on track to halt rising levels by 2025, WHO warns. BMJ: British Medical Journal (Online), 377, o1107.
Michicotl-Meneses, M. M., Thompson-Bonilla, M. del R., Reyes-López, C. A., García-Pérez, B. E., López-Tenorio, I. I., Ordaz-Pichardo, C., & Jaramillo-Flores, M. E. (2021). Inflammation markers in adipose tissue and cardiovascular risk reduction by pomegranate juice in obesity induced by a hypercaloric diet in Wistar rats. Nutrients, 13(8), 2577.
Muthmainnah, M., Salim, L. A., Nurmala, I., Nadia, A., & Salsabila, A. C. (2025). Enhancing Health Education Using Edutainment: A Quantitative Study in Malang Regency, Indonesia. Media Publikasi Promosi Kesehatan Indonesia (MPPKI), 8(5), 326–336.
Nugraha, G. I., Amalia, F., Imadudda’wah, F., Ariyanto, E. F., Ghozali, M., & Fatimah, S. N. (2024). Combination of diethylpropion with dietary intervention results in body weight and fat loss with preserved muscle mass in obese patients. Medicine, 103(39), e39908.
Organization, W. H. (2025). Global nutrition targets 2030: childhood overweight brief.
Simmonds, M., Llewellyn, A., Owen, C. G., & Woolacott, N. (2016). Predicting adult obesity from childhood obesity: a systematic review and meta?analysis. Obesity Reviews, 17(2), 95–107.
Soto-Molina, H., Pizarro-Castellanos, M., & Rosado-Pérezo, J. (2014). Six-month efficacy and safety of amfepramone in obese Mexican patients.
Trisnawati, Y. (2026). Analisis Status Gizi Terhadap Hasil Pemeriksaan GDS Pada Remaja SMA Purwokerto. Jurnal Bina Cipta Husada: Jurnal Kesehatan Dan Science, 22(1), 60–67.
Van Hulst, A., Zheng, S., Argiropoulos, N., Ybarra, M., Ball, G. D. C., & Kakinami, L. (2025). Overweight and obesity in early childhood and obesity at 10 years of age: a comparison of World Health Organization definitions. European Journal of Pediatrics, 184(4), 270.
Vásquez-Reyes, S., Bernal-Gámez, M., Domínguez-Chávez, J., Mondragón-Vásquez, K., Sánchez-Tapia, M., Ordaz, G., Granados-Portillo, O., Coutiño-Hernández, D., Barrera-Gómez, P., & Torres, N. (2024). The Effects of Novel Co-Amorphous Naringenin and Fisetin Compounds on a Diet-Induced Obesity Murine Model. Nutrients, 16(24), 4425.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 N Anna Sakinah Liana Rahmawati, Rizky Abdullah, Izzah Faridh

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International. that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
















