The Role of Mesenchymal Stem Cells in Stroke Recovery: A Regenerative Medicine Approach with Medical Rehabilitation
DOI:
https://doi.org/10.58344/jws.v4i4.1404Keywords:
Stroke, mesenchymal stem cells, rehabilitation, MSC therapy, stroke recoveryAbstract
This study examines the role of mesenchymal stem cells (MSCs) in stroke recovery, exploring their regenerative properties and potential to enhance rehabilitation outcomes. Stroke remains a leading cause of long-term disability, with limited treatment options for functional recovery. This research investigates how MSC therapy, combined with conventional rehabilitation methods, can improve motor and cognitive function in stroke patients. Using case studies and patient care records, the study analyzes the effectiveness of MSC therapy in promoting neural repair, reducing disability levels, and improving overall quality of life. The findings suggest that MSC therapy significantly enhances functional recovery when integrated with rehabilitation, particularly when cerebrospinal fluid treatment is used before MSC administration. Imaging and biomarker analyses support these results, showing improvements in neurogenesis, synaptic plasticity, and reduced neuroinflammation. This research highlights the synergistic effects of MSC therapy and rehabilitation, presenting a promising approach to stroke recovery. The study also emphasizes the need for further research to optimize MSC-based treatments, refine delivery methods, and evaluate long-term safety and effectiveness. The implications of this study contribute to the development of integrated therapeutic strategies for stroke patients, offering a more holistic approach to recovery.
References
Abdumutallibovna M. M., & O. O. B. (2025). Stem cell therapy: Advances and ethical considerations. Ethiopian International Journal of Multidisciplinary Research, 12(03), 16–20. https://www.eijmr.org/index.php/eijmr/article/view/2707
Andrzejewska A., D. S. L. B. & J. M. (2021). Mesenchymal stem cells for neurological disorders. Advanced Science, 8(7), Article 2002944.
https://doi.org/10.1002/advs.202002944
Arabpour M., S. A. & R. N. (2021). Anti-inflammatory and M2 macrophage polarization- promoting effect of mesenchymal stem cell-derived exosomes. International Immunopharmacology, 97, Article 107823. https://doi.org/10.1016/j.intimp.2021.107823 Berlet R., A. S. B. B. W. Z. J. S. N. S. A. C. B. G.-P. B. P. B. S. F. E. L. T. A. R. M. G. R. G.-
P. J. V. & B. C. V. (2021). Combination of stem cells and rehabilitation therapies for ischemic stroke. Biomolecules, 11(9), Article 1316.
https://doi.org/10.3390/biom11091316
Dabrowska Andrzejewska, A., Janowski, M., & Lukomska, B., S. (2021). Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: Therapeutic outlook for inflammatory and degenerative diseases. Frontiers in Immunology, 11, Article 591065. https://doi.org/10.3389/fimmu.2020.591065
Dadfar, S., Yazdanpanah, E., Pazoki, A., Nemati, M. H., Eslami, M., Haghmorad, D., & Oksenych, V. (2024). The Role of Mesenchymal Stem Cells in Modulating Adaptive Immune Responses in Multiple Sclerosis. Cells, 13(18), 1556.
https://doi.org/10.3390/cells13181556
Feigin, V. L., Owolabi, M. O., Abd-Allah, F., Akinyemi, R. O., Bhattacharjee, N. V, Brainin, M., Cao, J., Caso, V., Dalton, B., & Davis, A. (2023). Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization–Lancet Neurology Commission. The Lancet Neurology, 22(12), 1160–1206.
Gallego, E. M., & Zurita Castillo, M. (2024). Mesenchymal stem cell therapy in ischemic stroke trials. A systematic review. Regenerative Therapy, 27, 301–306. https://doi.org/10.1016/j.reth.2024.03.026
Kaminska, A., Radoszkiewicz, K., Rybkowska, P., Wedzinska, A., & Sarnowska, A. (2022). Interaction of Neural Stem Cells (NSCs) and Mesenchymal Stem Cells (MSCs) as a Promising Approach in Brain Study and Nerve Regeneration. Cells, 11(9), 1464. https://doi.org/10.3390/cells11091464
Karvandi, M. S., Sheikhzadeh Hesari, F., Aref, A. R., & Mahdavi, M. (2023). The neuroprotective effects of targeting key factors of neuronal cell death in neurodegenerative diseases: The role of ER stress, oxidative stress, and neuroinflammation. Frontiers in Cellular Neuroscience, 17.
https://doi.org/10.3389/fncel.2023.1105247
Khandia, R., Gurjar, P., Priyanka, Romashchenko, V., Al-Hussain, S. A., & Zaki, M. E. A.
(2024). Recent advances in stem cell therapy: efficacy, ethics, safety concerns, and future directions focusing on neurodegenerative disorders – a review. International Journal of Surgery, 110(10), 6367–6381. https://doi.org/10.1097/JS9.0000000000001609
Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J. (2021). Mesenchymal stem cell therapy for ischemic stroke: a look into treatment mechanism and therapeutic potential. Journal of neurology, 268, 4095–4107.
Li, Y., Xue, J., Ma, Y., Ye, K., Zhao, X., Ge, F., Zheng, F., Liu, L., Gao, X., Wang, D., & Xia,
Q. (2025). The complex roles of m6A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases. Neural Regeneration Research, 20(6), 1582–1598. https://doi.org/10.4103/NRR.NRR-D-23-01872
Liu, J., Wang, J., Hu, B., Zou, F., Wu, C., Shen, J., & Zhang, W. (2023). Olfactory ensheathing cells and neuropathic pain. Frontiers in Cell and Developmental Biology, 11. https://doi.org/10.3389/fcell.2023.1147242
Lv, B., Zhang, X., Yuan, J., Chen, Y., Ding, H., Cao, X., & Huang, A. (2021). Biomaterial- supported MSC transplantation enhances cell–cell communication for spinal cord injury. Stem Cell Research & Therapy, 12(1), 36. https://doi.org/10.1186/s13287-020-02090-y
Paredes-Espinosa, M. B., & Paluh, J. L. (2022). Human stem cell–derived neurons and neural circuitry therapeutics: Next frontier in spinal cord injury repair. Experimental Biology and Medicine, 247(23), 2142–2151. https://doi.org/10.1177/15353702221114099
Santos, M. F. dos, Roxo, C., & Solá, S. (2021). Oxidative-Signaling in Neural Stem Cell- Mediated Plasticity: Implications for Neurodegenerative Diseases. Antioxidants, 10(7), 1088. https://doi.org/10.3390/antiox10071088
Umer, A., Khan, N., Greene, D. L., Habiba, U. E., Shamim, S., & Khayam, A. U. (2023). The Therapeutic Potential of Human Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Premature Ovarian Failure. Stem Cell Reviews and Reports, 19(3), 651– 666. https://doi.org/10.1007/s12015-022-10493-y
Zeng, C.-W. (2023). Multipotent Mesenchymal Stem Cell-Based Therapies for Spinal Cord Injury: Current Progress and Future Prospects. Biology, 12(5), 653. https://doi.org/10.3390/biology12050653
Zhang, Y., Dong, N., Hong, H., Qi, J., Zhang, S., & Wang, J. (2022). Mesenchymal stem cells: therapeutic mechanisms for stroke. International Journal of Molecular Sciences, 23(5), 2550.
Zhao, Q., Han, Z., Wang, J., & Han, Z. (2021). Development and Investigational New Drug Application of Mesenchymal Stem/Stromal Cells Products in China. Stem Cells Translational Medicine, 10(S2), S18–S30. https://doi.org/10.1002/sctm.21-0083
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Deby Susanti Pada Vinski, Bruna Sinjari, Endang Ernandini, Natasha Cinta Vinski, Andi Kurniawan Nugroho
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International. that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
